A key factor in the treatment of Parkinson’s disease is the effectiveness of medications. However, over time, patients may often experience a decrease in the effectiveness of their medications, a phenomenon known as “wearing off.” This process is particularly noticeable with the use of levodopa, when the duration of the drug’s effect shortens, and symptoms appear earlier than the next dose is due. The wearing off phenomenon affects not only motor symptoms but also non-motor symptoms, which become fluctuating in nature. Research shows that a significant portion of patients treated with levodopa may experience this issue, regardless of how many years they have been on the medication. Therefore, it is…